| Date | Location | Result | |
| Dec 28, 2021 | Memphis, TN | Texas Tech 34, Mississippi State 7 | Box score |
| Nov 25, 2021 | Starkville, MS | Ole Miss 31, Mississippi State 21 | Box score |
| Nov 20, 2021 | Starkville, MS | Mississippi State 55, Tennessee St. 10 | Box score |
| Nov 13, 2021 | Auburn, AL | Mississippi State 43, Auburn 34 | Box score |
| Nov 06, 2021 | Fayetteville, AR | Arkansas 31, Mississippi State 28 | Box score |
| Oct 30, 2021 | Starkville, MS | Mississippi State 31, Kentucky 17 | Box score |
| Oct 23, 2021 | Nashville, TN | Mississippi State 45, Vanderbilt 6 | Box score |
| Oct 16, 2021 | Starkville, MS | Alabama 49, Mississippi State 9 | Box score |
| Oct 02, 2021 | College Station, TX | Mississippi State 26, Texas A&M 22 | Box score |
| Sep 25, 2021 | Starkville, MS | LSU 28, Mississippi State 25 | Box score |
| Sep 18, 2021 | Memphis, TN | Memphis 31, Mississippi State 29 | Box score |
| Sep 11, 2021 | Starkville, MS | Mississippi State 24, NC State 10 | Box score |
| Sep 04, 2021 | Starkville, MS | Mississippi State 35, Louisiana Tech 34 | Box score |